Resveratrol Products Exposed

People around the globe are using resveratrol supplements to look and feel younger. Because of the incredibly high demand, there are now more products on the market than ever. The bad news is that not all of them are effective.

I set out to find the top supplements for myself. I got a chance to compare over twenty products. View the Top 5 Resveratrol Supplements.

free radicals

Free Radicals and Aging

In recent years free radicals, also called “reactive oxygen species”, have been implicated in the development of cancer and cardiovascular disorders, which are the two major causes of mortality in developed countries. Moreover, many scientists consider that the gradual weakening of body functions known as aging, is a result of the slow but insidious work of these “little enemies”.

What are these “free radicals” and where do they appear from? They are in fact very simple compounds of oxygen, in which the innocent molecule has acquired an extra electron. Unfortunately, the formation of free radicals is a natural process, which will go on as long as one breathes oxygen. The formation of free radicals is accelerated by several factors such as environmental pollutants, UV light, and nuclear radiation. Free radicals are very reactive particles and they aggressively attack all the surrounding molecules within the cell. The attacked molecules become oxidized making them structurally damaged and even toxic for the body. Free radicals are rather indiscriminate their attack, so everything - such as DNA molecules, proteins, or lipids (the scientific name for fats) - that gets in their way becomes oxidised. The initial damage caused by free radicals can lead to further alteration of cellular function. It is known that our cells have the potential to divide quickly and to grow much faster than they do normally. The normal growth and regular development of the human body requires very complex interactions between hundreds of genes within the fragile DNA molecule. Cells in which the “genetic messenger” DNA is damaged by free radicals sooner or later lose the ability to control their own division; and uncontrolled growth leads to the appearance of malignant tumors.

Other consequences of free radical activities are cardiovascular disorders such as atherosclerosis. In this case lipids (fats) oxidized by free radicals play the major role. Oxidized lipids are toxic for the organism and they induce chronic inflammatory reactions within the walls of the blood vessels. This gradually leads to the blockage of vessels which thus lose their ability to supply blood to the organs. The arteries of the heart are most frequently affected, thus giving rise to heart disease and later to myocardial infarction (heart attack). The blockage of blood-vessels supplying the brain leads to a “stroke”, often causing permanent brain-damage.

Due to the frequency of atherosclerosis in the population, the oxidation of lipids has attracted much attention from scientists. In the laboratory it is easy to observe that the lipids from blood (normally light yellow) are quickly converted into brown oxidation products. Outside the laboratory a similar process can be easily observed if butter (which consists mostly of saturated lipids) is kept without refrigeration for a long time. The results are even more visible on hot summer days when the temperatures are closer to the 37°C (98°F) of our body. Talking about foods and oxidation I should mention vegetable oils, which are highly recommended as the healthy substitute for saturated animal fats like butter. Every housewife knows that, unlike butter, vegetable oils stay fresh without refrigeration for months. The same is happening inside our bodies - unsaturated vegetable fats successfully resist the attacks of free radicals and (if they are present in appropriate quantities) provide a powerful protection against atherosclerosis.

It would be unfair to say that Nature or God were unaware of the problem of free radicals when humans were created. Several mechanisms exist within the body which eliminate or neutralise the majority of them. Two important enzymes, called superoxide dismutase and catalase, convert most free radicals back into harmless oxygen compounds. Without these enzymes people would probably be “burned out” already in childhood. Another interesting enzyme called paraoxonase can prevent the accumulation of toxic oxidized lipids in the body. A laboratory strain of mice that lacks this enzyme develops atherosclerosis much faster then normal animals. Recently it has been shown that people with “weak” paraoxonase genes have a significantly greater chance of developing atherosclerosis early in life.

Vitamins with antioxidative properties form another natural line of defense against free radicals. These are vitamin A (derived from -carotene), vitamin C (ascorbic acid) and vitamin E (-tocopherol), which “catch” free radicals and neutralise them. Unlike anti-oxidative enzymes, which are produced only in strictly controlled quantities, vitamins enter the body with our food; and thus the amounts in the body can successfully be increased by eating the right diet.

The well-developed technique of gene manipulation allows scientists to create new organisms which are more resistant to oxidation due to the modification of genes producing anti-oxidative enzymes. The results of these experiments demonstrate that the life span can be significantly increased if the negative effects of oxidation are suppressed. For example, artificial strains of the fruit fly Drosophila, which possess increased amounts of the above-mentioned antioxidative enzymes catalase and superoxide dismutase have their average life span as long as 75 days compared with the 40 days of the normal fly. For us this 35 days difference is not great, but for the fly it is almost a second life! Another experiment was done with mice. The genetically modified mice, which were made more resistant to the action of free radicals in a similar way, lived 30% longer than normal animals. These experiments indicate that aging and life expectancy are at least partly determined by the ability of the organism to fight oxidation.

What can scientists offer to help humans? At the moment, the choice is not very big. In the near future gene manipulation will scarcely be applied to humans, due to ethical considerations and also (and in fact mainly) for technical reasons. So everybody has to try to be happy and live as long as possible with the genes inherited from their parents. Fortunately however, we can manipulate the amounts of antioxidant vitamins which we obtain from food. Many experiments have demonstrated that antioxidants are able to prevent the free-radical-induced conversion of normal cells into cancerous ones. Also the oxidation of lipids can be reduced to undetectable levels, if antioxidants are present in sufficient amounts. Several large-scale studies with the aim of investigating the disease-preventive effects of diets enriched by antioxidative vitamins have been carried out. The data from these experiments indicate that the risk of heart disease is significantly lower in people who consume a vitamin E - rich diet. The lowest risk was in people who consumed the highest amounts of vitamin E, achievable only by supplementation. Their chances of developing heart disease were almost halved, compared to people who consumed a “normal” diet. Similar results were obtained for diets rich in vitamin C.

There are also data about the beneficial effects of diets rich in vitamin A. The positive effect of this vitamin is stronger in smokers, who are particularly exposed to the damaging action of free radicals.

Another question is whether antioxidants can help to prevent grave consequences, such as myocardial infarction, if atherosclerosis has already occurred. Currently there no drugs that can “clean” the blocked arteries, and complex surgery is the only way to restore blood flow through damaged vessels. Two studies that aimed to find the effects of the high vitamin E doses on progression of atherosclerosis have been performed. According to the first study the occurrence of myocardial infarction (heart attack) was reduced by 38% in vitamin E users, and in another study the reduction was 77% !

But in spite the above-mentioned data concerning the positive effects of antioxidants, doctors in general do not recommend them as food supplements in order to decrease the risk of heart disease, protect from cancer and increase longevity. For example, the biggest USA medical body, the American Heart Association falls short of recommending pure vitamins as food supplements; the Association only recommends natural foods rich in vitamins. The reasons for that are not primarily medical but moral, legal, and financial. The doctor cannot prescribe even the most innocent products until their safety and usefulness have been proven in formal clinical trials. Pharmaceutical companies eager to bring their products to market usually finance these long and expensive trials. But pharmaceutical companies are not interested in studying antioxidants, because they do not expect great profits from the sale of these relatively cheap products. Also, because antioxidants have been well known for many years, they cannot be patented in order to protect their manufacturer from competition.


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Resveratrol Misspellings

Thank you for viewing the above article, entitled “Free Radicals and Aging.” Resveratrol is a very commonly misspelled word. To help more people find this page I have compiled a list of the most common spelling errors.

  • rezveratrol, resveratol, reservatrol, reveratrol, reseveratrol. reservatol, revatroll, rezveritrol, resvertrol, resveratro

Other Names for Resveratrol

Manufacturers often use shorter names to market their products with since ‘resveratrol’ doesn’t exactly roll off the tongue. Some examples include Eternal RezV, Pure RezV Pro, ResVer XP, Youth ResV Pro and Vital Rez V. The following are correct terms you will often see tied into many brand name supplements.